Pair Name	Quercetin, Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Inhibition-->ROS accumulation
Gene Regulation	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Phosphorylation	MAPK1	hsa5594
	Down-regulation	Expression	MMP9	hsa4318
	Down-regulation	Expression	MYC	hsa4609
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
In Vivo Model	Into the right hind limb of each nude mouse, 2×10⁶ 4 T1 TNBC cells were injected subcutaneously. One week later, the mice were randomly divided into four groups (n = 3): control group (0.9% saline); Que group (50 mg/kg Que); AC group (5 mg/kg Dox plus 50 mg/kg Cyc); and AC plus Que group (5 mg/kg Dox plus 50 mg/kg Cyc plus 50 mg/kg Que).
Result	Que could attenuate AC-induced cardiotoxicity by inhibiting ROS accumulation and activating ERK1/2 pathway in cardiomyocytes, but interestingly, Que could enhance the antitumor activity of AC by inhibiting ROS accumulation and ERK1/2 pathway in TNBC cells. In addition,in vivo studies further confirmed that Que could enhance the chemotherapeutic effect of AC against TNBC while it reduced the injury of cardiotoxicity induced by AC

Pair Name	Quercetin, Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	ABCB1	hsa5243
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
Result	These findings demonstrated that quercetin is important in MDR and may be developed into a new reversal agent for cancer chemotherapy.

Pair Name	Quercetin, Doxorubicin
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	ABCB1	hsa5243
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	CASP3	hsa836
	Up-regulation	Expression	CASP8	hsa841
	Up-regulation	Expression	CASP9	hsa842
In Vitro Model	K-562	Blast phase chronic myelogenous leukemia	Homo sapiens (Human)	CVCL_0004
Result	These findings demonstrated that quercetin is important in MDR and may be developed into a new reversal agent for cancer chemotherapy.